GTO is an abbreviation of:
- A gate turn-off thyristor
- Geographic targeting order, an order issued by the United States Secretary of Treasury
- Geostationary transfer orbit, an intermediate orbit around the Earth
- The station code of Gorton railway station in Greater Manchester, England
- Grand Touring Over, the International Motor Sports Association category for production cars over 2500 cc (later revised to 3000 cc)
- Gran Turismo Omologato (Italian for Grand Touring Homolgamated), a model name used on several automobiles:
- Great Teacher Onizuka, the manga, anime, live-action, and movie
- Guanajuato, Mexico's state abbreviation
- Ready for Labour and Defence of the USSR, the Soviet physical culture training programme
- Ronny & the Daytonas's debut song
- The GTOs (Girls Together Outrageously), a late 1960s "band" closely associated with Frank Zappa and featuring Pamela Des Barres
- Greater Than One, a pop/gabber husband and wife band formed in 1985
- Golgi tendon organ, a proprioceptive sensory receptor organ
- Gaussian-type orbital - compare also Slater-type orbital (STO)
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